The role of nuclear factor I-C in tooth and bone development
Roh Song-Yi, 박주철,
소속 상세정보
( Roh Song-Yi ) - Seoul National University School of Dentistry Department of Oral Histology-Developmental Biology
박주철 ( Park Joo-Cheol ) - Seoul National University School of Dentistry Department of Oral Histology-Developmental Biology
KMID : 0355620170430020063
Abstract
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Kruppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
키워드
Nuclear factor I-C; Dentinogenesis; Osteogenesis; Osteoporosis
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